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What are the Covid-19 recombinants "X" Designated in 2022 so far?

Sars-coV-2 recombinants XD, XE, XF, XG, XH, XJ, XK, XL, XM, XN, XP, XQ, XR & XS designated.

Sars-coV-2 recombinants XD, XE, XF, XG, XH, XJ, XK, XL, XM, XN, XP, XQ, XR & XS designated.

April 24, 2022. | 4.30 Minutes read |  Sars-coV-2  variants.

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US class, Variant of Concern, Omicron’s Lineages BA.2, BA.2.12.1, BA.1.1 & BA.1.1.529, are circulating in the USA. X+ recombinants emerged recently, and a few cases of XG & XS recombinants were sequenced in the USA. What are the covid-19 recombinants X designated in 2022 so far?.

According to WHO, about Covid-19 variants, “Viruses, like SARS-CoV-2, change over time and will continue to change the more they circulate. Sometimes, variants of the virus may develop. A variant is where the virus contains at least one new change to the original virus. ​”

WHO has already given the solution to end the pandemic. If you have missed the words “will(variants) continue to change the more they circulate.” Maintaining social distancing still makes a big difference in the emergence of covid variants.

Emerged in the United Kingdom, XE recombinant is only popular among all X+ so far. Other recombinants did not get much attention from the public.

Surprisingly, for the second year in a row, Covid-19 was the third leading cause of death in the United States in 2021, trailing heart disease and cancer, according to preliminary data from the Centers for Disease Control and Prevention.

It is important to know and focus on preventing Heart disease and cancer too.

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WHO recommended a Highly successful covid-19 therapy

Apart from vaccines, are there any effective treatments for covid-19 available?. Absolutely, Yes!.

On Friday, April 22, 2022, WHO recommended highly successful Covid-19 therapy, “WHO made a strong recommendation for nirmatrelvir and ritonavir, sold under the name Paxlovid, for mild and moderate Covid-19 patients at highest risk of hospital admission, calling it the best therapeutic choice for high-risk patients to date.”

According to WHO’s Director-General press conference statement released on April 13, 2022, “At present, there are a number of Omicron sub-lineages we’re following closely, including BA.2, BA.4 and BA.5 and another recombinant detected, made up of BA.1 and BA.2.”

 “This virus has over time become more transmissible and it remains deadly, especially for the unprotected and unvaccinated that don’t have access to health care and antivirals.”

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Understanding Mutations, Lineage, and Variants

Several widely used naming systems classify the virus’s emerging forms, relying on rules established by genomics experts to identify the branches and twigs of the Covid-19 (SARS-coV-2) family tree. The nomenclature used in different systems and press reports can be confusing.

A mutation is a single change in the genome of a virus. Mutations occur frequently, but only in rare instances do they change the characteristics of the virus.

A variant is a virus with one or more mutations in its genome.

A lineage is a group of viruses that share a common ancestor genetically.

A sublineage is a group of similar viruses, within a lineage.

A subvariant is a sublineage of a variant, most often referring to the variant of concern.

What Are the new X Covid-19 recombinant viruses sequenced in 2022?

XD – New Recombinant lineage of Delta and BA.1, France and Denmark lineage, 25 sequences as of February 5, 2022.

XE – New recombinant lineage of BA.1 and BA.2, UK lineage. According to UKHSA, there are 1,179 XE sequences in the UK data as of April 5, 2022, with 1,125 XE cases in England.

According to WHO, this lineage is 10% more transmissible than any other Omicron variant. 

UKHSA said that “Earlier published growth rates for XE were not significantly different from BA.2, but using the most recent data up to 30 March 2022, XE has a 12.6 % higher growth rate than BA.2. XE’s growth advantage reached 20.9 % over the most recent three weeks.”

XF – New Recombinant lineage of Delta and BA.1, UK lineage, 30 sequences as of February 17, 2022.

XG – New Potential BA.1-BA.2 recombinant lineage with 140 new sequence designations. 107 sequences in Denmark, UK, US, and Germany as of March 2, 2022.

XH – Potential BA.1-BA.2 recombinant of new lineage with 42 new sequences designations, (43 sequences in Denmark) as of February 13, 2022.

XI – Here comes the Politics? United Nations public health avoided NU and XI, for XI UN’s Spokeswoman Dr.Margaret Harris said, “XI because it’s a common surname and we have agreed [to] naming rules that avoid using place names, people names, animal, etc. to avoid stigma.”

XJ – New BA.1-BA.2 recombinant lineage with 17 new sequence designations found in Finland (66 sequences as of March 25).

end of March, several cases of Omicron XJ, the most recent variant, were discovered first in Finland. 

April first week, In Italy, a case has now been identified and validated. Thailand reported XE and XJ recombinant variants. According to experts, there is no evidence that the XJ is more dangerous at this point.

XK – Potential recombined BA.2-BA.1.1 new lineage with 15 new sequence designations. (1.4% sequences in Roeselare, Belgium lineage).

XL – Potential BA.1-BA.2 recombinant new lineage with 38 new sequence designations, UK lineage (38 sequences in Britain as of March 16, 2022).

XM – Potential BA.1.1-BA.2 Recombinants in Germany, Netherlands, Croatia, and Denmark, 50 Sequences as of March 31, 2022.

XN – Potential BA.1*- BA.2 Recombinant, UK – England lineage, 104 Sequences as of March 29, 2022.

XO – No data found.

XP – Potential BA.1.1 – BA.2 Recombinant, UK – Scotland lineage, 57 Sequences as of March 27, 2022.

XQ – Potential BA.1.1 – BA.2 Recombinant, England and Wales lineage 49 Sequences as of March 27, 2022.

XR – Potential BA.1.1 – BA.2 Recombinant, UK – Wales lineage 43 Sequences as of March 11, 2022.

XS – Potential Delta – BA.1.1 Recombinant, US lineage, 37 Sequences as of March 27, 2022.

That’s all the recombinants so far we got in 2022, we have eight more months left, Let’s see what is going to happen.

What are the X recombinants currently not present?

XA – Recombinant lineage with parental B.1.1.7 and B.1.177, UK lineage with 43 sequencesNot present after January 30, 2021.

XB – New Recombinant lineage with Parental lineages B.1.634 and B.1.631, Central and North America lineage. Discussed in Pango-designation issue, Formally B.1.628. 3,219 sequences have been recorded since the XB lineage was discovered, Not present after October 21, 2021.

XC – Recombinant lineage with parental lineages AY.29 and B.1.1.7, Japan lineage, 24 sequences in the XC have been detected since the lineage was identified as not present after October 16, 2021.

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Do not worry about the variants

Viruses are continually changing due to mutations, and these mutations can sometimes result in a new virus strain. Some varieties appear and then go, while others remain. There will be more versions in the future.

Slowing the virus’s spread by protecting yourself and others can help slow the emergence of new variants.

Yes, You make the difference.

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